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I have had Polycythemia vera for 25 years. I was started on hydroxyurea two months ago and recently developed severe petechial hemorrhaging. I was admitted to the hospital with a platelet count of 9,000. I received a six pack of platelets and over seven days (being off the medication) my platelet count had climbed to 74,000. As of Sunday, July 5th, it was at 139,000 (off the medication for ten days). I was given the medication to help prevent the POTENTIAL of developing a blood clot. I have managed my Polycythemia vera pretty well without medication for 25 years (I do take baby aspirin) and wish I had never taken this.

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Effect of Hydroxyurea Therapy on Resting Energy Expenditure in Children With Sickle Cell Disease.

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C) Kidney: loss of tubules with fibrosis and inflammation of the interstitium and increased eosinophilic matrix in the glomerular tuft of animals in the vehicle and hydroxyurea groups, but not present in the gene therapy group.

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